This research aimed to compare the perception that children in the pediatric palliative care setting have of their emotional well-being, or that expressed by the parents, with the perception held by the professionals involved in their care. Children themselves, or their parents, report more positive evaluations of emotional well-being than health professionals. Sociodemographic and disease variables do not seem to have a direct influence on this perception; rather, it is more likely that children, parents, and professionals focus on different aspects and that children or parents need to hold on to a more optimistic vision.